Extravasation of Vincristine

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Extravasation injuries.

OBJECTIVES To evaluate the time and type of treatment following extravasation from intravenous infusion and the sequelae of the injuries. METHOD The charts of 12 patients who were referred to the Plastic and Orthopaedic Services at the University Hospital of the West Indies were reviewed. The study period was between May 2003 and January 2007. Data were collected on age, gender, site of extra...

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Extravasated iodinated contrast media are toxic to the surrounding tissues, particularly to the skin, producing an acute local inflammatory response that sometimes peaks in 24 to 48 hours. The acute tissue injury resulting from extravasation of iodinated contrast media is possibly related primarily to the hyperosmolality of the extravasated fluid. Despite this, the vast majority of patients in ...

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Subcutaneous Extravasation of Sr-89: Usefulness of Bremsstrahlung Imaging in Confirming Sr-89 Extravasation and in the Decision Making for the Choice of Treatment Strategies for Local Radiation Injuries Caused by Sr-89 Extravasation

A male patient in his 20s presented at our clinic with pain caused by bone metastases of the primitive neuroectodermal tumor, and Sr-89 was administrated to palliate the pain. After receiving the injection, the patient complained of a slight burning pain at the catheterized area. Slight reddening and small circular swelling (diameter, 0.5 cm) were observed at the catheterized area. Sr-89 extrav...

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Stereocontrolled total synthesis of (+)-vincristine.

An efficient total synthesis of (+)-vincristine has been accomplished through a stereoselective coupling of demethylvindoline and the eleven-membered carbomethoxyverbanamine presursor. Demethylvindoline was prepared by oxidation of 17-hydroxy-11-methoxytabersonine, followed by regioselective acetylation with mixed anhydride method. Although an initial attempt of coupling by using demethylvindol...

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Infiltration and extravasation.

Infiltration and extravasation are risks of intravenous administration therapy involving unintended leakage of solution into the surrounding tissue. Consequences range from local irritation to amputation. While immediate action using appropriate measures (ie, dilution, extraction, antidotes, and supportive treatments) can decrease the need for surgical intervention, many injuries may be prevent...

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ژورنال

عنوان ژورنال: Actas Dermo-Sifiliográficas (English Edition)

سال: 2010

ISSN: 1578-2190

DOI: 10.1016/s1578-2190(10)70847-7